دانلود رایگان مقاله سنتز بر اساس QbD و شناسایی پلی آکریل آمید صمغ فیبر ذرت

ABSTRACT

The aim of present investigation was to utilize quality by design approach for the synthesis of polyacrylamide corn fibre gum (PAAm-g-CFG) from corn fibre gum (CFG) by varying concentration of acrylamide and initiator. The spectral analysis (ATR-FTIR, 1H NMR, DSC, X-ray and Mass spectroscopy) was conducted to assure grafting copolymerization of CFG with acrylamide. The powder flow properties confirm the porous nature of PAAm-g-CFG. The grafted copolymer dispersion showed shear thinning behaviour that follows Herschel Bulkley model. The viscoelastic analysis suggested viscous liquid like nature of PAAm-g-CFG and its viscosity increases with increase in concentration of PAAm-g-CFG. The mucoadhesive strength of synthesized PAAm-g-CFG was found to be higher than moringa oleifera gum, karaya gum, guar gum, xanthan gum, chitosan and gelatin. Further, the results pointed toward enhanced thermal stability of PAAm-g-CFG. Thus, PAAm-g-CFG has a great potential to be used in food and pharmaceutical industry.

4. Conclusion

The graft copolymer of corn fibre gum was successfully synthesized employing quality by design approach. The technique suggested 5 g acrylamide, 0.4 g ammonium persulfate (initiator) and 80 ◦C temperature was necessary to obtain pure PAAm-gCFG with 552 ± 2.4% grafting and 6.52 ± 0.34% yield and 110 ± 2.8% grafting efficiency. Further, the synthesized grafted copolymer bears highest mucoadhesive strength as compared to moringa oleifera gum, karaya gum, guar gum, xanthan gum, chitosan and gelatin suggesting high pharmaceutical benefits. In addition, the PAAm-g-CFG behaves as shear thinning liquid thatfollows Herschel Bulkley model. The viscoelastic analysis pointed towards liquid like viscous liquid nature of PAAm-g-CFG, indicating its application to food as well as pharmaceutical industry.