دانلود رایگان مقاله انگلیسی بررسی اختلال در مورد بیماری اسهال حاد در یک جمعیت تعریف شده جغرافیایی - هینداوی 2017

Acute diarrheal disease (ADD) is a common cause of morbidity and mortality in children under 5 years of age. Understanding of the etiology of ADD is lacking in most low and middle income countries because reference laboratories detect limited number of pathogens. The objective of this study was to determine the feasibility to conduct a comprehensive casecontrol study to survey diarrheal pathogens among children with and without moderate-to-severe ADD. Materials and Methods. Microbiology and molecular-based techniques were used to detect viral, bacterial, and parasitic enteropathogens. The study was conducted in Bucaramanga, Colombia, after Institutional Review Board approval was obtained. Results. Ninety children less than 5 years of age were recruited after a written informed consent was obtained from parents or guardians. Forty-five subjects served as cases with ADD and 45 as controls. Thirty-six subjects out of 90 (40.0%) were positive for at least one enteropathogen, that is, 20 (44.4%) cases and 16 (35.5%) controls. Conclusions. The three most common enteric pathogens were enteroaggregative E. coli (10.0%), Norovirus (6.7%), and Salmonella spp. (5.6%). The E. coli pathogens were 18.8% of all infections making them the most frequent pathogens. Half of ADD cases were negative for any pathogens.

5. Conclusion

This pilot case-control study showed that children with ADD and healthy controls had high proportion of enteropathogens detected in stools, suggesting a high level of healthy carriage state within this population. More than 50% of the cases of ADD were negative for any enteropathogen, indicating that in half of the cases the cause of ADD remains unknown. Bacteria were commoner than viruses and most common organisms were E. coli pathotypes. The proportion of coinfections among cases of ADD was higher than in controls suggesting that coinfection, rather than single infections, may contribute to ADD in this population.