دانلود رایگان مقاله انگلیسی صرع خوش خیم rolandic و پراکسیسم عمومی: مطالعه 13 بیمار. - الزویر 2018

ABSTRACT

Purpose: To present a retrospective study of 13 children with benign epilepsy with centrotemporal spikes (BECTS), also known as benign rolandic epilepsy (BRE), associated with generalized spikes and waves as the only EEG manifestation at onset. Method: Charts of children with typical clinical criteria of BRE electroclinically followed-up between February 2000 and February 2015 were reviewed. Results: Among 309 patients who met the electroclinical criteria of BRE, we identified 13 children who presented with the typical clinical manifestations but who, on the EEG, only had generalized paroxysms at onset that continued along the course of the syndrome. Generalized spike-and-wave discharges were observed in all patients when awake and during sleep (100%). During the evolution no particular electroclinical pattern was observed. The patients responded well to antiepileptic drugs, such as valproic acid and levetiracetam. Outcome was good in all patients. Conclusions: We found evidence that patients with BRE may have generalized EEG discharges at onset as the sole manifestation lasting throughout the course of the syndrome. In some, focal paroxysms developed later. The course was benign. In our group of patients, clinical features and evolution were similar to those of typical cases of BRE. Response to valproic acid and levetiracetam was found to be particularly good.

5. Conclusion

In this retrospective study we found patients with typical clinical manifestations of BRE who had generalized EEG discharges as the sole manifestation at onset lasting throughout the course of the syndrome. In some, focal paroxysms developed later. Clinical features and evolution were the same as in the typical cases of BRE. The patients responded well to valproic acid and levetiracetam. Up to now, in these patients no particular electroclinical evolution was found. Further studies should be performed to confirm these findings so as to manage these patients accordingly.