دانلود رایگان مقاله انگلیسی Oocytes سلول های بنیادی - الزویر 2018

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عنوان فارسی

Oocytes سلول های بنیادی

عنوان انگلیسی

Oocytes from stem cells

صفحات مقاله فارسی

0

صفحات مقاله انگلیسی

20

سال انتشار

2018

نشریه

الزویر - Elsevier

فرمت مقاله انگلیسی

PDF

نوع مقاله

ISI

نوع نگارش

مقالات مروری

رفرنس

دارد

پایگاه

اسکوپوس

کد محصول

E9778

رشته های مرتبط با این مقاله

زیست شناسی، پزشکی

گرایش های مرتبط با این مقاله

علوم سلولی و مولکولی، خون و آنکولوژی

مجله

بهترین روش ها و تحقیقات مامایی و زنان و زایمان بالینی - Best Practice & Research Clinical Obstetrics & Gynaecology

دانشگاه

Ovarian Biology Laboratory - Department of Anatomy and Developmental Biology - Monash University - Australia

کلمات کلیدی

Oocytes، فولیکول زایی، باروری، سلول های بنیادی، سرطان، شیمی درمانی

doi یا شناسه دیجیتال

https://doi.org/10.1016/j.bpobgyn.2018.07.006

برای سفارش ترجمه این مقاله با کیفیت عالی و در کوتاه ترین زمان ممکن توسط مترجمین مجرب سایت ایران عرضه؛ روی دکمه سبز رنگ کلیک نمایید.

چکیده

Abstract

Folliculogenesis describes the process of activating an oocyte-containing primordial follicle from the ovarian reserve, and its development to the mature ovulatory stage. This process is highly complex and is controlled by extra- and intra-ovarian signalling events. Oocyte competence and capacity for fertilisation to support a viable pregnancy is acquired during folliculogenesis. Cancer, and cancer-based therapies can negatively affect this process, compromising fertility. Currently, preservation of fertility in these patients remains limited to surrogacy, oocyte freezing, oocyte donation or in vitro maturation (IVM). Recent reports of stem cells being used to produce fully competent oocytes, and subsequently healthy offspring in mice, has opened up a novel avenue for fertility preservation. However, translating these findings into human health first relies on enhancing our understanding of follicle growth, and mimicking its intricacies in vitro. Indeed, the future of oocytes from stem cells in humans comes with many possibilities, but currently faces several technical and ethical obstacles.

نتیجه گیری

Summary

The ability to convert mouse ESC or iPSC into competent oocytes and subsequently to embryos and offspring has been achieved, but success rates remain low. Further research is needed to improve these success rates and to confirm that the offspring are genetically normal. There is no evidence that human ESC or iPSC can be converted into competent oocytes. Should this become possible and practicable, then the ensuing ethical and safety issues will need careful investigation and discussion. In addition, further research is needed to improve the safety, efficacy and success rates of IVM of human oocytes, one of the key steps in transforming stem cells into competent oocytes. Until these barriers are overcome, it will remain necessary to use the current methods of fertility preservation.

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