دانلود رایگان مقاله انگلیسی اثر تزریق ویتامین C با دوز بالا در بیماران مبتلا به کمبود گلوکز 6 فسفات دی هیدروژنیزه - هینداوی 2017

Vitamin C supplementation is generally regarded as benign. )ere has been a resurgence of interest in the general medical community regarding the use of vitamin C most notably in the care of sepsis. Nonetheless, caution must be taken if supraphysiologic vitamin C supplementation is being administered as it should be considered a medication just like any other. We present a case of hemolysis in a glucose-6-phosphate dehydrogenase- (G6PD-) de9cient patient receiving high-dose vitamin C infusions for his rheumatoid arthritis.

4. Conclusion

Our case showed that G6PD de9ciency should be considered any time hemolytic anemia ensues after a medication is administered. Additionally, our case highlighted that an acute hemolytic anemia associated with methemoglobinemia by no means diagnostic could lead the clinician to a potential diagnosis of G6PD de9ciency with large amounts of hemolysis. Finally, our case exempli9ed the importance of understanding the limitation of qualitative testing in an acute hemolytic reaction. )ough supraphysiologic vitamin C is considered benign in most people, it can be associated with major morbidity and even mortality in G6PD-de9cient patients. Care must be taken to remember that, when administered at high doses, vitamin C is a medication with side eLects just like any other medication one would prescribe. For the clinician who will be utilizing vitamin C at supraphysiologic doses, screening should be considered prior to utilization, particularly in ethnicities with a higher prevalence, to avoid potential false negatives during treatment and, more importantly, iatrogenic harm to the patient.