دانلود رایگان مقاله انگلیسی تنظیم ترانسکریپشنال و اپی ژنتیکی رشد لنفوسیت T - الزویر 2018

Invariant Natural Killer T (iNKT) cells are a heterogeneous innate T cell population that recognizes lipid antigens. Despite the monospecific nature of their T cell receptor, iNKT cells differentiate into stable sublineages during thymic development, before foreign antigen encounter. How iNKT cell subsets acquire and maintain their functional programs is a central question in innate lymphocyte biology. Global transcriptional and epigenetic profiling of iNKT subsets has provided insights into the internal wiring of these subsets that defines their identity. Comparison of the iNKT transcriptional programs with those of other adaptive and innate lymphocyte lineages revealed common core regulatory circuits that may dictate effector functions. In this review, we summarize recent advances on the molecular mechanisms involved in iNKT cell development.

Conclusions

Although significant progress has been made regarding the identification of the individual transcription factors that control iNKT cell development, how these are coordinated with each other and what is the chromatin background that enables proper gene expression is currently unclear. Recent studies have started illuminating the nuclear events in iNKT cells that mediate the functional properties of mature iNKT cell subsets and revealed the gene expression programs that establish and maintain iNKT cell identity. The advance of techniques that allow global gene expression analysis at the single-cell level in combination with powerful genetic mouse models will contribute to the delineation of the developmental trajectories of iNKT cells and the corresponding gene regulatory networks.