دانلود رایگان مقاله انگلیسی بررسی تاثیرپذیری سلامتی و پرسشنامه بیماری پارکینسون در بیماران مبتلا به پارکینسون - NCBI 2017

Abstract

Background: The responsiveness of a measurement instrument is important for understanding its ability to detect changes in the progression of a disease. We examined and compared the internal and external responsiveness of the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson’s Disease Questionnaire (PDQ-39) in patients with Parkinson’s Disease (PD). Methods: Seventy-four patients with PD were evaluated using the SF-36 and PDQ-39 at baseline and again after one year. In addition, their motor signs, motor difficulties of daily living, and depressive symptoms were assessed as external criteria. The internal responsiveness was examined using effect size, standardized response mean, and the Wilcoxon signed rank test. The external responsiveness was examined using receiver operating characteristic curves, correlation analyses, and regression models. Results: Both instruments were partially sensitive to changes during the 1-year follow-up and able to discriminate between patients with improved versus deteriorated motor signs. In addition, both were similarly responsive to changes in the motor difficulties of daily living; the SF-36 appeared to be more sensitive than the PDQ-39 to changes in depressive symptoms. Conclusions: The SF-36 and the PDQ-39 were acceptably internally and externally responsive during the 1-year follow-up.

Conclusions

This is the first study that uses a clinician-judged evaluation of motor signs and a psychological measure as external criteria to evaluate the internal and external responsiveness of HRQoL measures in patients with PD. Overall, both the SF-36 and the PDQ-39 were partially sensitive to change in the 1-year follow-up and discriminated between patients with improved and with deteriorated motor signs. In addition, the SF-36 and the PDQ-39 were similarly responsive to changes in the motor difficulties of daily living, and the SF-36 was more sensitive than was the PDQ-39 to changes in depressive symptoms.