دانلود رایگان مقاله انگلیسی بیومارکرهای بالقوه برای بیماری تنفسی تشدید شده NSAID - هینداوی 2017

عنوان فارسی
بیومارکرهای بالقوه برای بیماری تنفسی تشدید شده NSAID
عنوان انگلیسی
Potential Biomarkers for NSAID-Exacerbated Respiratory Disease
صفحات مقاله فارسی
0
صفحات مقاله انگلیسی
9
سال انتشار
2017
نشریه
هینداوی - Hindawi
فرمت مقاله انگلیسی
PDF
کد محصول
E6118
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پزشکی
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بیماری های ریوی
مجله
واسطه های التهاب - Mediators of Inflammation
دانشگاه
Department of Allergy and Clinical Immunology - Kyungpook National University School of Medicine - Daegu - Republic of Korea
چکیده

Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups.

نتیجه گیری

5. Conclusion


The most useful biomarker of NERD is urinary LTE4. Urinary LTE4 level can be used for distinguishing the phenotype (including subtypes) and for predicting the response to desensitization and prognosis. Sputum/blood eosinophil counts are also biomarkers that can be used to identify the endotype of NERD and to monitor the course of treatment. Serum periostin levels and HLA-DPB1 (∗0301 and genetic polymorphisms) are suggested as useful biomarkers for predicting NERD phenotypes.