Over the past 10 years, acute care surgery has become widely accepted as a distinct surgical specialty and practice paradigm, encompassing 3 areas of surgical practice: trauma surgery, emergency general surgery, and surgical critical care.1,2 The recognition and formalization of the specialty continue to grow (Fig. 1), as evidenced by the increasing number of acute care surgery services at institutions throughout the US.3 There are currently 20 nonACGME, American Association for the Surgery of Trauma (AAST)-approved acute care surgery training fellowship programs, up from 7 just 5 years ago.4 Acute care surgeons provide time-sensitive care for both trauma and nontrauma surgical emergencies. There are multiple challenges in caring for these patients, including around-the-clock readiness for the provision of comprehensive care across a spectrum of disciplines, the constrained time for preoperative optimization of the patient, and the greater potential for intraoperative and postoperative complications due to the often-emergent, high-complexity, and high-acuity nature of care. Although the morbidity and mortality of acute care surgery patients, especially in the more mature disciplines of trauma and surgical critical care, have steadily improved, ensuring optimal outcomes of all patients continues to evolve. Improving outcomes will require an ongoing commitment from a diverse range of health care services, professionals, and organizations, and an emphasis on high-quality, comprehensive contemporary research.