دانلود رایگان مقاله انگلیسی ملاتونین در آنالیز پیچیده توبروز اسکلروزیس با روش های مدلسازی ریاضی - هینداوی 2017

Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n = 76) and the children from the control, nonepileptic group (n = 36). To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters. The dim light melatonin onset (DLMO) parameters were also estimated from the model. Results and Conclusions. Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group. The profiles for the epileptic and TSC groups were found to be similar. For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures.

5. Conclusion

A larger study will be needed to better understand the disturbances of circadian rhythms in TSC individuals. Based on our findings, we believe that such studies may provide more insight into the relationship between the TSC symptoms and melatonin diurnal profile. We believe that the mathematical modelling will be helpful in such task. Moreover, the presented mathematical modeling seems to be useful in estimation of the DLMO parameters.