دانلود رایگان مقاله انگلیسی اختلال روده و آرتریت روماتوئید: ارتباط بین میکروبیوتای روده و پاتوژنز آرتریت روماتوئید - هینداوی 2017

Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome’s role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process. Studies with intestinal microbiota have shown that rheumatoid arthritis is characterized by an expansion and/or decrease of bacterial groups as compared to controls. In this review, we present evidence linking intestinal dysbiosis with the autoimmune mechanisms involved in the development of rheumatoid arthritis.

6. Microbiota as a Possible Mechanism for Rheumatoid Arthritis Prevention

Current research projects are focused on prevention with biological drugs that inhibit antibody formation or activate T cells [87]. Recent findings showed intestinal dysbiosis as a major advance in our understanding of rheumatoid arthritis. Nevertheless, there is no study demonstrating the antigen or antigens that trigger the autoimmune process. Logical indications point mucosal dysbiosis as an attractive site for elucidating autoimmunity pathways, particularly the mechanisms that induce loss of immune tolerance and specific mechanisms by which a person evolves from a preclinical to a clinical disease.

Gut microbiota has been shown to play role in rheumatoid arthritis although the mechanism of this association remains obscure. Understanding these mechanisms is crucial for a better treatment efficacy and personalized patient management [67]. Plasticity of microbiome may allow a specific or systematic manipulation of a certain intestinal microbiota associated with host diseases [88], speculating that, in the future, this manipulation could change therapeutic strategies in subjects with rheumatoid arthritis.