دانلود رایگان مقاله انگلیسی مطالعات همخوانی ژنوم درباره ارتباط هوش و سلامتی جسمانی، بیماری و میرایی - الزویر 2019

عنوان فارسی
چیزی که مطالعات همخوانی سراسر ژنوم درباره ارتباط هوش و سلامتی جسمانی، بیماری و میرایی آشکار می سازد
عنوان انگلیسی
What genome-wide association studies reveal about the association between intelligence and physical health, illness, and mortality
صفحات مقاله فارسی
0
صفحات مقاله انگلیسی
27
سال انتشار
2019
نشریه
الزویر - Elsevier
فرمت مقاله انگلیسی
PDF
نوع مقاله
ISI
نوع نگارش
مقالات مروری
رفرنس
دارد
پایگاه
اسکوپوس
کد محصول
E9405
رشته های مرتبط با این مقاله
پزشکی، روانشناسی
گرایش های مرتبط با این مقاله
ژنتیک پزشکی، روانشناسی بالینی
مجله
نظر رایج در روانشناسی - Current Opinion in Psychology
دانشگاه
Centre for Cognitive Ageing and Cognitive Epidemiology - Department of Psychology - University of Edinburgh - United Kingdom
doi یا شناسه دیجیتال
https://doi.org/10.1016/j.copsyc.2018.07.005
چکیده

Abstract


The associations between higher intelligence test scores from early life and later good health, fewer illnesses, and longer life are recent discoveries. Researchers are mapping the extent of these associations and trying to understanding them. Part of the intelligence-health association has genetic origins. Recent advances in molecular genetic technology and statistical analyses have revealed that: intelligence and many health outcomes are highly polygenic; and that modest but widespread genetic correlations exist between intelligence and health, illness and mortality. Causal accounts of intelligence-health associations are still poorly understood. The contribution of education and socio-economic status—both of which are partly genetic in origin—to the intelligence-health associations are being explored. Until recently, an article on DNA-variant commonalities between intelligence and health would have been science fiction. Thirty years ago, we did not know that intelligence test scores were a predictor of mortality. Fifteen years ago, there were no genome-wide association studies. It was less than five years ago that the first molecular genetic correlations were performed between intelligence and health outcomes. These former blanks have been filled in; however, the fast progress and accumulation of findings in the field of genetic cognitive epidemiology have raised more questions.

نتیجه گیری

Conclusion


Intelligence has predictive power for many health outcomes. Part of that association is genetic. The genes involved, and the causal pathways of the associations are being explored.


Funding


IJD and SEH are supported by the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology which is funded by the UK Medical Research Council and Biotechnology and Biological Sciences Research Council (Grant No. MR/K026992/1). WDH is supported by Age UK (Disconnected Mind programme).


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