دانلود رایگان مقاله انگلیسی تعامل کارکردی بین سیگنالینگ ملاتونین و RNA های غیر کدومی - الزویر 2018

Melatonin was discovered in the pineal gland and first came to be known as a biochemical synchronizer of circadian rhythm. The molecular mechanisms underlying the broad-spectrum actions of melatonin are not restricted to its interaction with proteins but it also has functional effects after influencing RNA species that have no protein-coding potential. In this review we discuss the current understanding of the melatonin-mediated modulation of noncoding RNA (ncRNA) pathways under different physiological and pathological conditions. We also delineate the impact of specific ncRNAs in controlling the synthesis of melatonin. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin and to better explore the emerging functions of the noncoding transcriptome.

Concluding Remarks

The noncoding transcriptome and ncRNA interactome are now considered important regulators for most aspects of molecular and cellular biology. In this review we summarize the interplay between melatonin signaling and several types of regulatory ncRNAs, including miRNAs, lncRNAs, and piRNAs; this expands our knowledge of mechanisms underlying melatonin-regulated gene expression to a previously unforeseen extent. Also covered is an alternative role for melatonin in functional interactions with housekeeping ncRNAs, such as affecting the production of rRNAs in cancer suppression. These data provide clues for further clarification of ncRNA biology and additional mechanisms underlying the broad range of melatonin’s actions (see Outstanding Questions).