دانلود رایگان مقاله انگلیسی اثر پیوند Fecal Microbiota در کودک مبتلا به نشانگان توره - هینداوی 2017

Tourette syndrome is a neuropsychiatric disorder with onset in childhood. New therapies are needed to e5ectively manage and treat this condition. Gut microbiota can a5ect central physiology and function via the microbiota-gut-brain axis. Here, we report a case in which fecal microbiota transplantation (FMT) is used to treat a child with Tourette syndrome, whose symptoms ameliorated dramatically in the following eight weeks.

3. Discussion

Here, we report the case of a patient with TS, tentatively prescribed with tiapride and probiotics at >rst, which alleviated severity of the patient’s symptoms. However, the patient experienced a relapse of symptoms, and tiapride and probiotics could not achieve remission again. Subsequently, we introduced FMT to the patient, which dramatically ameliorated his tic symptoms. /is case shows evidence for signi>cant eFcacy and safety when treating TS with FMT, suggesting that rebalancing GI microbiota might o5er a promising new biological therapy for TS. However, long-term eFcacy and potential adverse reactions remain unclear and warrant randomized clinical trials with large samples. /e interaction between the gut and the brain remains unclear. Previous studies have indicated that the brain-gut pathway is bidirectional and that there is potentially a complex relationship between the gut microbiota and the brain [8, 12]. Further studies are urgently needed to determine whether and how gut microbiota contribute to the etiology of TS.