دانلود رایگان مقاله سنتز، فعالیت ضد باکتری و ضد قارچ از مشتقات پیریمیدین بنزوتیازول جدید

Abstract

A new series of 5-amino-6-(benzo[d]thiazol-2-yl)-2-(2-(substitutedbenzylidene)hydrazinyl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives (7a–k) were synthesized. All the newly synthesized compounds were screened for their in vitro antibacterial activity, against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Streptococcus pyogenes and for antifungal activity against Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Penicillium marneffei and Mucor. Compounds 7b, 7e, 7f, 7g, 7h and 7j showed excellent in vitro antibacterial activity and antifungal activity than the standard drugs. All the compounds were characterized by IR, 1 H NMR, 13C NMR, LCMS mass and C, H, N analyses.

5. Conclusion

In conclusion, we have described a simple and efficient protocol for the synthesis of novel benzothiazole pyrimidine derivatives (7a–k) with good yields. The antibacterial and antifungal activities of all the synthesized compounds were investigated. It is evident that newly synthesized compounds, 7b, 7e, 7f, 7g, 7h and 7j have excellent antibacterial and antifungal activities. For the above compounds a significant improvement in their antibacterial and anti fungal activities has been examined over the earlier reported compounds (Maddila et al., 2011). These novel class of new benzothiazole pyrimidine derivatives reported have a probability to emerge as a valuable lead series with great potential to be used as antibacterial and antifungal agents, and as promising candidates for further efficacy evaluation.