دانلود رایگان مقاله انگلیسی ارتباط علت بالقوه بین سندرم خودایمنی انسولین و اسید آلفا لیپوئیک - الزویر 2019

قیمت خرید این محصول

رایگان

دانلود مقاله انگلیسی سفارش ترجمه این مقاله

عنوان فارسی

ارتباط علت بالقوه بین سندرم خودایمنی انسولین و اسید آلفا لیپوئیک: گزارش دو مورد

عنوان انگلیسی

Potential cause-effect relationship between insulin autoimmune syndrome and alpha lipoic acid: Two case reports

صفحات مقاله فارسی

0

صفحات مقاله انگلیسی

4

سال انتشار

2019

نشریه

الزویر - Elsevier

فرمت مقاله انگلیسی

PDF

نوع مقاله

ISI

نوع نگارش

مقالات پژوهشی (تحقیقاتی)

رفرنس

دارد

پایگاه

اسکوپوس

کد محصول

E9498

رشته های مرتبط با این مقاله

پزشکی

گرایش های مرتبط با این مقاله

غدد و متابولیسم

مجله

تغذیه - Nutrition

دانشگاه

Center for Endocrine and Metabolic Diseases - IRCSS Universita Cattolica del Sacro Cuore - Italy

کلمات کلیدی

سندرم خودایمنی انسولین، ااسید آلفا لیپوئیک، پزشکی شخصی شده، هیپوگلیسمی HLA-DRB1، مواد غذائی طبی نوتریسوتیکال

doi یا شناسه دیجیتال

https://doi.org/10.1016/j.nut.2018.04.010

برای سفارش ترجمه این مقاله با کیفیت عالی و در کوتاه ترین زمان ممکن توسط مترجمین مجرب سایت ایران عرضه؛ روی دکمه سبز رنگ کلیک نمایید.

چکیده

ABSTRACT

Objectives: Insulin autoimmune syndrome (IAS) or Hirata disease is a rare cause of autoimmune hypoglycemia with apparent high insulin levels and anti-insulin autoantibodies and was first described by Hirata in Japan in 1970. IAS cases are usually related to exposure to sulfhydryl-containing drugs, which stimulate the production of insulin autoantibodies. Among sulfhydryl-containing compounds, alpha lipoic acid (ALA) has recently emerged as a cause of IAS. After the first observations of ALA-induced IAS were reported in Japan in 2006, an increasing number of cases related to ALA administration have been described. An Italian group recently reported on six cases of IAS of which one was associated with HLA-DRB1*04:06 and the remaining five with HLA-DRB1*04:03. This suggests that the latter is potentially involved in the genetic susceptibility of people of European descent to IAS. Methods: Here, we describe two new cases of IAS in women that were triggered by ALA. Results: Both cases are associated with HLA-DRB1*04:03 and confirm the evidence that HLA-DRB1*04:03 rather than HLA-DRB1*04:06 is specifically related to IAS susceptibility in Europeans. Conclusions: Case reports of ALA-induced hypoglycemic episodes highlight the need for greater care in prescribing ALA supplementation as well as the identification of specific and personalized therapeutic targets.

نتیجه گیری

Conclusions

It is interesting to note that ALA supplementation could exert a contrasting effect. While ALA is prescribed to potentiate the effect of insulin and reduce body weight, ALA also might determine an autoimmune syndrome and stimulate the production of circulating anti-insulin antibodies, which seem to limit the effect of endogenous insulin. Case reports of ALA-induced hypoglycemic episodes impose the need for greater care in prescribing ALA supplementation as well as the identification of specific and personalized therapeutic targets. Furthermore, when investigating differential diagnoses of hypoglycemia, physicians must be mindful of possible supplement self-prescription and consider IAS when more specific causes of hypoglycemia have been excluded.

برچسب‌ها: دانلود رایگان مقالات انگلیسی پزشکی، دانلود رایگان مقالات isi