دانلود رایگان مقاله انگلیسی نوروسیستی سرکوزیس در کودکان دارای بیماری تشنج: یک مطالعه مقطعی - هینداوی 2018

Background. Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. Tere is a lack of data on the prevalence of NCC and its clinical characteristics among those with seizure in South-Western Nepal. Aims and Objectives. To study the prevalence and clinical characteristics of NCC in children with seizures. Material and Methods. All children admitted to Universal College of Medical Sciences, a tertiary hospital in South-Western Nepal with seizures during 2014–16, were tested for NCC. NCC was diagnosed by neuroimaging [computerized tomography (CT) scan or magnetic resonance imaging (MRI)]. We used logistic regression to test the association between NCC with participants’ characteristics and clinical symptoms. Results. Among 4962 inpatient children, 168 (104 boys and 64 girls) had seizures (138 with generalized tonic clonic seizures (GTCS) and 30 with focal seizures). 43% of children with seizures had CT scan confrmed NCC. Te prevalence of NCC in the oldest children (13–16 years) was signifcantly greater (57.1% versus 15.6%) compared to the youngest (0–4 years) one (� < 0.001). Among 72 children with NCC, the proportions of children with vesicular, calcifed, and colloidal stages were 76% (� = 35), 18% (� = 13), and 6% (�=2), respectively. Children with focal seizures had 13% more NCC compared to those with GTCS but the result was statistically not signifcant. Te adjusted odds of having NCC among 5–8 years, 9–12 years, and 13–16 years children were 6.6 (1.78–24.60), 11.06 (2.74–44.60), and 14.47 (3.13–66.96), respectively, compared to 0–4-year-old children. Reoccurrence of seizures within the frst 3 months of taking antiepileptic drug in those with NCC was approximately 3 times higher compared to those without NCC (11% versus 4%, � = 0.084). Conclusions. Tis study shows that NCC contributes signifcantly to higher prevalence of seizures in children in South-Western region of Nepal.

5. Conclusion

In summary, our study supports the earlier fndings that neurocysticercosis usually afects children with increasing prevalence in teenagers and adolescents. Te proportion of females with NCC was higher than males. Te most common clinical manifestation of NCC is seizure where GTCS is common compared to focal seizures. Loss of consciousness and headache were other common clinical fndings in NCC. Te occurrence of fever was signifcantly low in cases of NCC. Vesicular stage of NCC followed by calcifed stage was the common radiological fndings in CT scan head. Any child presenting with a frst episode of afebrile seizure should be evaluated with an imaging of brain (CT scan/MRI), especially if they present afer 3 years of age, provided that other causes of seizure are ruled out.