دانلود رایگان مقاله انگلیسی فرضیه پنهان در "نظریه آزاد" همخوانی های اپی ژنتیک سراسر ژنوم - الزویر 2019

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عنوان فارسی

فرضیه پنهان در "نظریه آزاد" همخوانی های اپی ژنتیک سراسر ژنوم

عنوان انگلیسی

Hidden hypotheses in ‘hypothesis-free’ genome-wide epigenetic associations

صفحات مقاله فارسی

0

صفحات مقاله انگلیسی

5

سال انتشار

2019

نشریه

الزویر - Elsevier

فرمت مقاله انگلیسی

PDF

نوع مقاله

ISI

نوع نگارش

مقالات مروری

رفرنس

دارد

پایگاه

اسکوپوس

کد محصول

E9408

رشته های مرتبط با این مقاله

پزشکی، روانشناسی

گرایش های مرتبط با این مقاله

ژنتیک پزشکی، روانشناسی بالینی

مجله

نظرات رایج در روانشناسی - Current Opinion in Psychology

دانشگاه

Department of Psychology - Institute of Psychiatry - Psychology and Neuroscience - King’s College London - UK

doi یا شناسه دیجیتال

https://doi.org/10.1016/j.copsyc.2018.07.009

برای سفارش ترجمه این مقاله با کیفیت عالی و در کوتاه ترین زمان ممکن توسط مترجمین مجرب سایت ایران عرضه؛ روی دکمه سبز رنگ کلیک نمایید.

چکیده

The recent interest in epigenetics within mental health research, from a developmental perspective, stems from the potential of DNA methylation to index both exposure to adversity and vulnerability for mental health problems. Genome-wide technology has facilitated epigenome-wide association studies (EWAS), permitting ‘hypothesis-free’ examinations in relation to adversity and/or mental health problems. In EWAS, rather than focusing on a priori established candidate genes, the genome is screened for DNA methylation, thereby enabling a more comprehensive representation of variation associated with complex disease. Despite their ‘hypothesis-free’ label, however, results of EWAS are in fact conditional on several a priori hypotheses, dictated by the design of EWAS platforms as well as assumptions regarding the relevance of the biological tissue for mental health phenotypes. In this short report, we review three hidden hypotheses —and provide recommendations — that combined will be useful in designing and interpreting EWAS projects.

نتیجه گیری

Conclusion

The recent interest in epigenetics, from a developmental perspective, stems from the potential of DNA methylation to index both exposure to adversity and vulnerability for mental health problems [2]. To this end, there has been substantial activity in examining EWASes of adversity-related disorders, such as conduct disorder [37] and psychosis [38]. Of interest, from these EWAS, DNAm in genes that underlie stress response, neurotransmitter activity and immune regulation have been identified. These preliminary findings may provide a useful framework for more in-depth investigations — potentially as CNS surrogates or biomarkers — of the biological pathogenesis of a mental health problem. However, we argue that understanding hidden hypotheses within the EWAS is an important first step in interpreting the results in relation to mental health phenotypes.

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