- مبلغ: ۸۶,۰۰۰ تومان
- مبلغ: ۹۱,۰۰۰ تومان
The recent interest in epigenetics within mental health research, from a developmental perspective, stems from the potential of DNA methylation to index both exposure to adversity and vulnerability for mental health problems. Genome-wide technology has facilitated epigenome-wide association studies (EWAS), permitting ‘hypothesis-free’ examinations in relation to adversity and/or mental health problems. In EWAS, rather than focusing on a priori established candidate genes, the genome is screened for DNA methylation, thereby enabling a more comprehensive representation of variation associated with complex disease. Despite their ‘hypothesis-free’ label, however, results of EWAS are in fact conditional on several a priori hypotheses, dictated by the design of EWAS platforms as well as assumptions regarding the relevance of the biological tissue for mental health phenotypes. In this short report, we review three hidden hypotheses —and provide recommendations — that combined will be useful in designing and interpreting EWAS projects.
The recent interest in epigenetics, from a developmental perspective, stems from the potential of DNA methylation to index both exposure to adversity and vulnerability for mental health problems . To this end, there has been substantial activity in examining EWASes of adversity-related disorders, such as conduct disorder  and psychosis . Of interest, from these EWAS, DNAm in genes that underlie stress response, neurotransmitter activity and immune regulation have been identified. These preliminary findings may provide a useful framework for more in-depth investigations — potentially as CNS surrogates or biomarkers — of the biological pathogenesis of a mental health problem. However, we argue that understanding hidden hypotheses within the EWAS is an important first step in interpreting the results in relation to mental health phenotypes.