دانلود رایگان مقاله انگلیسی دیابت و استرس اکسیداتیو - یک بررسی مختصر - الزویر 2016

Abstract

Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery. In order to encounter the deleterious effects of such species, body has got endogenous antioxidant systems or it obtains exogenous antioxidants from diet that neutralizes such species and keeps the homeostasis of body. Any imbalance between the RS and antioxidants leads to produce a condition known as ‘‘oxidative stress’’ that results in the development of pathological condition among which one is diabetes. Most of the studies reveal the inference of oxidative stress in diabetes pathogenesis by the alteration in enzymatic systems, lipid peroxidation, impaired Glutathione metabolism and decreased Vitamin C levels. Lipids, proteins, DNA damage, Glutathione, catalane and superoxide dismutase are various biomarkers of oxidative stress in diabetes mellitus. Oxidative stress induced complications of diabetes may include stroke, neuropathy, retinopathy and nephropathy. The basic aim of this review was to summarize the basics of oxidative stress in diabetes mellitus.

8. Conclusion

Oxidative stress has been demonstrated in many studies to participate in the progression of diabetes which plays important role during diabetes, including impairment of insulin action and elevation of the complication incidence. Antioxidants have already shown to be prospective in the treatment of diabetes both type 1 and type 2. Increase in the levels of oxygen and nitrogen free radicals (ROS/RNS) has been linked with lipid peroxidation, non-enzymatic glycation of proteins and oxidation of glucose which contributes toward diabetes mellitus and its complications. Most of the studies have shown relationship between oxidative stress and diabetes along with their complications related to heart, liver kidney and eye. Thus, oxidative stress seems to be more worrying in metabolic disorders specially diabetes type 2.