دانلود رایگان مقاله انگلیسی مکانیسم ضد تومور Curcumae Rhizoma بر اساس فارماکولوژی شبکه - هینداوی 2018

Curcumae Rhizoma, a traditional Chinese medication, is commonly used in both traditional treatment and modern clinical care. Its anticancer effects have attracted a great deal of attention, but the mechanisms of action remain obscure. In this study, we screened for the active compounds of Curcumae Rhizoma using a drug-likeness approach. Candidate protein targets with functions related to cancer were predicted by reverse docking and then checked by manual search of the PubMed database. Potential target genes were uploaded to the GeneMANIA server and DAVID 6.8 database for analysis. Finally, compound-target, target-pathway, and compound-target-pathway networks were constructed using Cytoscape 3.3. The results revealed that the anticancer activity of Curcumae Rhizoma potentially involves 13 active compounds, 33 potential targets, and 31 signaling pathways, thus constituting a “multiple compounds, multiple targets, and multiple pathways” network corresponding to the concept of systematic actions in TCM. These findings provide an overview of the anticancer action of Curcumae Rhizoma from a network perspective, as well as setting an example for future studies of other materials used in TCM.

5. Conclusions

Eight of the thirteen active compounds were selected by a DL strategy, and their potential targets were identified by PharmMapper and analyzed by network-related tools. The results revealed that the 13 active compounds exert their antitumor effects via 33 targets in 31 pathways.This is consistent with the TCM concept of “multiple compounds, multiple targets, and multiple effects.” Although further experiments are needed to provide support for our findings, this study provides a systematic view of the potential anticancer mechanisms of Curcumae Rhizoma from a network-based perspective.