دانلود رایگان مقاله ویتامین E کم کردن آسیب دیواره آئورت ناشی از الکل در موش

Abstract

Background: In this study the effect of chronic ethanol consumption on vascular wall abnormality via oxidative stress was examined. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rat vascular wall. Methods: Twenty-four male wistar rats were divided into three groups, namely, control, ethanol (4.5 g/kgBW intragastrically), and vitamin E treated ethanolic groups(VETE) (300 mg interagastrically). Results: After 6 weeks treatment of rats, the results revealed that along with a significant increase VSMC proliferation and aorta wall thickness with the increase in the level of Ox-LDL, protein carbonyl, as well as decrease total antioxidant capacity in animal that received ethanol compared to the control group. Significant amelioration of aorta wall changes, along restoration of the elevated level of Ox-LDL, protein carbonyl, lipid profile, and decreased level of total antioxidant capacity to that of controls were found in vitamin E-treated animals. Conclusions: These findings strongly support the idea that heavy and chronic ethanol consumption initiate atherosclerosis by oxidative stress, and that these effects can be alleviated by vitamin E as an antioxidant.

Conclusion

Our results clearly demonstrate that chronic ethanol consumption induce VSMCs proliferation and aorta wall thickness via oxidative stress and administration of vitamin E improve ethanol-induced oxidative stress by decreasing protein oxidation, Ox-LDL, and Hcy. Furthermore, vitamin E alleviated the ethanol einduced vascular structural change in aorta of ethanolic rats. Further research is, however, required to elucidate the mechanisms by which ethanol produces these vascular deficits in order to develop practicable prevention or treatment strategies for alcoholinduce adverse effects in cardiovascular system.