دانلود رایگان مقاله آنالیز زمان - فرکانس EEG داخل جمجمه در بیماران مبتلا به تشنج میوکلونیک

Abstract

Myoclonic seizures are defined as generalized seizures according to the classification of seizure by the International League Against Epilepsy (ILAE). The pathogenesis of myoclonic seizures is not yet clear. There are very few studies on the focal surgical treatment of myoclonic seizures. The aim of this study is to investigate the characteristics of myoclonic seizure onset in different bands of the intracranial electroencephalogram (EEG) and their dynamic changes in temporal and spatial evolution. We studied four patients with myoclonic seizures who were under the focal resection of the epileptogenic zone. We retrospectively analyzed the semiology, electrocorticogram (ECoG) and imaging data of these patients, and conducted time-frequency analysis of broadband ECoG activity. We found that myoclonic seizures without clinical lateralizing signs could be improved by the resection of the epileptogenic zone. The ECoG power in different frequency bands increased to a peak at 0.5 s before the clinical seizure onset and decreased quickly afterwards. The power of alpha activity was highest during the preictal and ictal periods. The central zone had higher power than the epileptogenic zone in all frequency bands during the preictal period, but this difference was not statistically significant. Our results suggest that myoclonic seizures in some patients might have a focal origination, with a fast bilateral propagating network in all frequency bands, especially the alpha band.

4.8. Statistical analysis

Repeated measures analysis of variance (ANOVA) and multivariate ANOVA under the general linear model in SPSS Statistics 17.0 software were performed using factors including: region (the resected zone, the central zone, and the zone NON), frequency band (infraslow-delta, theta, alpha, beta, gamma, and ripple), as well as measurement period (interictal, preictal, and ictal). The degrees of freedom were adjusted with a Greenhouse–Geisser correction whenever necessary. Meanwhile, some interactions among the studied factors were also evaluated, such as time and region, and frequency band and region. The repeated measures ANOVA was used to perform the pairwise comparisons for repeatedly measured data in different measurement periods for each region and each frequency band. Data in different regions of each measurement period were compared in a pairwise fashion using the means of the multivariate ANOVA. For post hoc analysis, LSD t-tests were used (Bonferroni t-tests were used in the case of lower bound value when epsilon < 0.7). P-values were considered statistically significant as follows: *P < 0.05, **P < 0.01, △P < 0.05,△△P < 0.01.