دانلود رایگان مقاله انگلیسی داروهای درمانی دیابت نوع 2 - الزویر 2017

ABSTRACT

Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide and a major economic burden. The prevalence of T2DM is rising, suggesting more effective prevention and treatment strategies are necessary. The aim of this narrative review is to summarize the pharmacologic treatment options available for patients with T2DM. Each therapeutic class is presented in detail, outlining medication effects, side effects, glycemic control, effect on weight, indications and contraindications, and use in selected populations (heart failure, renal insufficiency, obesity and the elderly). We also present representative cost for each antidiabetic category. Then, we provide an individualized guide for initiation and intensification of treatment and discuss the considerations and rationale for an individualized glycemic goal.

4. Conclusions

Pharmacologic treatment options available for patients with T2DM were summarized in this review. Mechanism(s) of action, proposed dose and position in treatment armamentarium, expected outcomes, safety issues and estimation of monthly cost are presented for each class of medication. Subsequently, a critical appraisal of current guidelines is provided aiming to an individualized consideration of glycemic targets. Having multiple choices in the armamentarium, therapeutic options should be tailored to the individual patient, combining efficacy, safety and the lower possible cost.