دانلود رایگان مقاله انگلیسی درمان با سلول های بنیادی عصبی - الزویر 2018

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عنوان فارسی

درمان با سلول های بنیادی عصبی - بررسی مختصر

عنوان انگلیسی

Neural stem cell therapy—Brief review

صفحات مقاله فارسی

0

صفحات مقاله انگلیسی

16

سال انتشار

2018

نشریه

الزویر - Elsevier

فرمت مقاله انگلیسی

PDF

نوع مقاله

ISI

نوع نگارش

مقالات مروری

رفرنس

دارد

پایگاه

اسکوپوس

کد محصول

E9777

رشته های مرتبط با این مقاله

زیست شناسی

گرایش های مرتبط با این مقاله

علوم سلولی و مولکولی

مجله

عصب شناسی بالینی و جراحی اعصاب - Clinical Neurology and Neurosurgery

دانشگاه

Department of Anatomy - Medical University of Lublin - Doktora Kazimierza Jaczewskiego - Poland

کلمات کلیدی

سلول های بنیادی عصبی؛ درمان NSC؛ درمان با سلول های بنیادی عصبی

doi یا شناسه دیجیتال

https://doi.org/10.1016/j.clineuro.2018.07.013

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چکیده

Abstract

Adult mammalian neural stem cells are unique because of their properties, such as differentiation capacity, self-renewal, quiescence, and also because they exist in specific niches, which are the subventricular zone (SVZ) and subgranular zone (SGZ) - the dentate gyrus of the hippocampus. SVZ is situated along the ependymal cell layer, dividing the ventricular area and subventricular zone. There are several sources of neural stem cells such as human embryonic stem cells, human fetal brain-derived neural stem/progenitor cells, human induced pluripotent stem cells, direct reprogrammed astrocytes. Stem cell sciences are a promising tool for research purposes as well as therapy. Induced pluripotent stem cells appear to be very useful for human neuron studies, allowing the creation of defined neuron populations, particularly for neurodevelopmental and neurodegenerative diseases as well as ischemic events. Neural stem cell sciences have a promising future in terms of stem cell therapy as well as research. There is, however, still a great need for further research to overcome obstacles.

نتیجه گیری

Conclusions

Neural stem cell sciences have a promising, yet distant future in terms of stem cell therapy as well as research. It enables a better understanding of the disease pathology and in the future may become a treatment option not only in neurodegenerative disease such as Parkinson’s disease or Huntington’s disease, but also in a post-stroke therapy, increasing the quality of life. Despite many human trials are still being planned, none of them have been successful so far. Moreover, many clinical trials are based on MSC, however researchers report that the number of MSC-derived neurons is extremely low and irrelevant for potential clinical use. There is still a great need for further research to overcome obstacles such as cell overgrowth and tumor growth as well as technical problems such as establishment of proper stem cell sources, appropriate quantity of stem cell transplants, choosing proper programming protocols and selection of the most profitable disease stage for treatment.

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