دانلود رایگان مقاله انگلیسی تعامل استرس شغلی و پلی مورفیسم BDNF Val66Met موثر بر افسردگی در کارکنان چینی - الزویر 2018

ABSTRACT

Background: Chronic exposure to job-related stress can lead to depression and BDNF polymorphism may play an important role in this process. The role of the stress × BDNF Val66Met interaction in depression has been studied widely using childhood stress, but few studies have utilized chronic stress in adulthood as a moderator. This study was to examine the chronic stress × BDNF Val66Met interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet. Methods: Using a cross-sectional design, 243 doctors and nurses were recruited from a general hospital in Beijing, and were assessed for depression with Self-rating Depression Scale (SDS), and the stress using the House and Rizzo's Work Stress Scale. The BDNF Val66Met polymorphism was genotyped. Results: There was a significant positive association between job stress and depressive scores (p < 0.001). No significant main effect of the BDNF Val66Met genotype on depressive symptoms was observed (p > 0.05). A statistically significant interaction between BDNF Val66Met and job stress on depressive symptoms was found (p < 0.05); individuals with Val/Val genotype showed a higher SDS score than Met allele carriers only in the low-stress group, without significant differences in SDS score between the BDNF Val66Met subgroups in medium- or high-stress group. Limitations: Limitations include cross-sectional study design, the small sample size only in healthcare workers and only one polymorphism in BDNF gene was analyzed. Conclusions: Our results suggest a close relationship between job-related stress and depression, and the interaction of the BDNF Val66Met polymorphism and chronic stress in adulthood may impact the depressive symptoms.

Contributors

Shu-Chang He and Xiang Yang Zhang were responsible for study design, statistical analysis, and manuscript preparation. Shu-Chang He, Shuang Wu, and Chao Wang were responsible for recruiting the subjects, performing the clinical rating and collecting the samples. XiangDong Du, Guangzhong Yin, Qiuwang Jia, Yingyang Zhang, Li Wang and Jair C. Soares were involved in evolving the ideas and editing the manuscript. Shu-Chang He and Xiang Yang Zhang were involved in writing the protocol, wrote the paper and were responsible for providing the funding for the study. All authors have contributed to and have approved the final manuscript.