دانلود رایگان مقاله فسفولیپاز C اولیه و اختلالات مغزی

Abstract

In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Among the primary PLC isozymes, PLCβ1, PLCβ4, and PLCγ1 are highly expressed and differentially distributed, suggesting a specific role for each PLC subtype in different regions of the brain. Primary PLCs control neuronal activity, which is important for synapse function and development. In addition, dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. In this review, we included current knowledge regarding the roles of primary PLC isozymes in brain disorders.

8. Conclusion

The activation of primary PLCs regulates various signaling events in the brain. Among primary PLCs, PLCb1, PLCb4, and PLCg1 are highly detected in the brain. Different distribution and regulation mechanism of each primary PLC isozyme contribute to their specific role in different regions of the brain. Although the results of many studies suggest the association of primary PLCs with various brain disorders, many questions still remain. We now need to understand more precisely the mechanism underlying how each primary PLC is involved in pathogenesis of brain disorders for the treatment of psychiatric and neurodegenerative disorders.