دانلود رایگان مقاله میکروپارتیکال سلول مشتق شده قرمز خون

ABSTRACT

The red blood cell (RBC) is historically the original parent cell of microparticles (MPs). In this overview, we describe the discovery and the early history of red cell-derived microparticles (RMPs) and present an overview of the evolution of RMP. We report the formation, characteristics, effects of RMP and factors which may affect RMP evaluation. The review examines RMP derived from both normal and pathologic RBC. The pathologic RBC studies include sickle cell anemia (SCA), sickle cell trait (STr), thalassemia intermedia (TI), hereditary spherocytosis (HS), hereditary elliptocytosis (HE), hereditary stomatocytosis (HSt) and glucose-6-phosphate dehydrogenase deficiency (G6PD).

4. Conclusion

This overview describes the history of the origin of microparticles as a concept. The evolving knowledge about MP formation, characteristics, effects and factors which may affect formation and function of MP derived from normal and abnormal RBC is then described. Accumulated knowledge, where the RBC serves as the paradigm, shows that microparticle formation is a fundamental biologic process of cell aging, cell survival and cell clearance. Underlying disorders of Hb synthesis, RBC membranes or red cell enzymes, increase micro-vesiculation, thereby increasing procoagulant effects, and decreased NO bioavailability, which contribute to the clinical phenotype of each syndrome where microparticle formation is increased.