دانلود رایگان مقاله آدنوکارسینوما ریه جهش KRAS G12V ناشی از تشعشع در یک فرد غیر سیگاری

abstract

The molecular profile of radiation-induced cancers remains poorly understood. This case report describes a 59-year-old male never smoker with a distant history of Hodgkin's lymphoma treated with mantle radiation who decades later develops primary lung adenocarcinoma within the prior radiation portal. Genomic profiling of the cancer demonstrated a KRAS G12V mutation. We briefly review the clinical entity of radiation-induced second malignancies and KRAS mutant lung adenocarcinoma. Although to date there is no standard molecularly targeted therapy available for KRAS mutant lung cancer, prior reports of activating EGFR mutations in a proportion of radiation-induced lung cancers suggest that a variety of genomic alterations may occur in these secondary malignancies. Given the potential to identify other molecularly defined subsets of lung cancer for which specific therapies exist, routine molecular profiling of these cases seems reasonable.

4. Conclusion

Recognizing the limitations of a case report, this case suggests that delayed radiation effects may be associated with G4T nucleotide transversions, resulting in KRAS G12V mutant lung adenocarcinoma. Although to date there is no standard molecularly targeted therapy available for KRAS mutant lung cancer, prior reports of activating EGFR mutations in a substantial proportion of radiation-induced lung cancers suggest that a variety of genomic alterations may occur in these secondary malignancies. Given the potential to identify other molecularly defined subsets of lung cancer for which specific therapies exist (including EGFR and potentially others), routine molecular profiling of these cases seems reasonable. This information may be particularly valuable in cases of radiation-induced lung cancer, as these cases may have inferior outcomes compared to de-novo malignancies.