دانلود رایگان مقاله انگلیسی نقش ROS میتوکندری در ایمنی آنتی باکتریال - وایلی 2017

Abstract

Reactive oxygen species (ROS) are essential participants of various innate immune cell responses against microorganisms and are also involved in many cellular regulatory pathways. It was believed that the main pool of ROS in the innate immune cells is generated by the NADPH oxidase enzymatic complex. However, it was discovered recently that mitochondrial ROS (mtROS) are equally important for the functioning of the immune system. mtROS play an important role in the development of the antimicrobial innate immune responses. The present mini-review summarizes the most recent data on the role of mtROS in the antibacterial immunity. The principles of mtROS formation and possible mechanisms of their generation under the activation of innate immunity are highlighted in this review. We also speculate on the possibilities of using activators of mtROS production in clinical practice. This article is protected by copyright.

Conclusions Taken together, the data presented here highlight the essential role of mtROS in innate immunity. mtROS formation in phagocytizing neutrophils and monocytes/macrophages can be promoted using endogenous metabolites and exogenous agents including widely used drugs and immunostimulators. This strategy can be used to enhance the bactericidal effect of these cells and to more effectively eliminate pathogens in the organism. Activators of mtROS formation can be used for the therapy and prevention of chronic infections and inflammatory diseases that develop in settings of primary or secondary NAPDH oxidase deficiencies.