ترجمه مقاله نقش ضروری ارتباطات 6G با چشم انداز صنعت 4.0
- مبلغ: ۸۶,۰۰۰ تومان
ترجمه مقاله پایداری توسعه شهری، تعدیل ساختار صنعتی و کارایی کاربری زمین
- مبلغ: ۹۱,۰۰۰ تومان
Abstract
Electrical stimulation may influence cell behavior associated with proliferation, differentiation, and migration, among others. The need for electrical tools to interact with living cells has pushed the technology to progressively develop less invasive devices. Technologies like energy harvesting have enabled wireless biological applications. Here we report the use of a photovoltaic microcell array (PVMA) based on silicon, as a wire-free interface to stimulate single cells with high spatial resolution. We demonstrate the effectivity of this microtool on osteoblast cells. The electrical stimulation triggered intracellular calcium transients as a response in 46% of the cells. The reduced dimension of the PVMA and its capacity to work in visible light show its potential for the wireless life science explorations.
Conclusions
Silicon-based PVMA were successfully fabricated by means of microelectronic technology. Their reduced dimensions, planar morphology, simple fabrication process and their capability to harvest energy from light and instantaneously convert it to an electric stimulus provides a stimulation tool of single cells without the limitation of external cables and electrodes. Furthermore, induction of cytosolic Ca2+ transients triggered by the electrical stimuli generated by the PVMA, on which osteoblasts cells were grown, shows the feasibility of this approach towards localized activation of excitable cells in a simple way. In summary, this technology affords new possibilities for the electric stimulation of single cells as a tool for life science explorations as well as for future biomedical applications based on controlling bioelectric signaling.