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  • پشتیبانی: ۴۲۲۷۳۷۸۱ - ۰۴۱
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دانلود رایگان مقاله انگلیسی سرطان سینه همزیست و ازدیاد پلاکت های خون - هینداوی 2018

عنوان فارسی
سرطان سینه همزیست و ازدیاد پلاکت های خون: چگونه چالش های درمانی را نشان دادیم
عنوان انگلیسی
Coexistent Breast Cancer and Essential Thrombocythemia: How We Addressed the Therapeutic Challenges
صفحات مقاله فارسی
0
صفحات مقاله انگلیسی
5
سال انتشار
2018
نشریه
هینداوی - Hindawi
فرمت مقاله انگلیسی
PDF
نوع نگارش
Case report
رفرنس
دارد
کد محصول
E10452
رشته های مرتبط با این مقاله
پزشکی
گرایش های مرتبط با این مقاله
خون و آنکولوژی
مجله
گزارشات موردی در هماتولوژی - Case Reports in Hematology
دانشگاه
Department of Internal Medicine - University of Florida College of Medicine - USA
doi یا شناسه دیجیتال
https://doi.org/10.1155/2018/2080185
۰.۰ (بدون امتیاز)
امتیاز دهید
چکیده

Essential thrombocythemia (ET) occurring with breast cancer is uncommon; the therapeutic approach varies and poses a challenge. A 65-year-old female presented to us after being diagnosed with hormone positive, HER2-negative infiltrating ductal carcinoma. She had a platelet count of 600 thou/cu mm. Her JAK2 mutation was positive. Bone marrow biopsy showed increased megakaryocytes. She was diagnosed with ETin the setting of breast cancer. She underwent breast conservation surgery after which aspirin was resumed. Anticipating thrombocytopenia during chemotherapy and given the absence of data combining hydroxyurea with standard chemotherapy used for breast cancer, we felt it prudent to delay cytoreductive therapy for her ET until after completion of breast cancer treatment. Her average platelet count during chemotherapy was 480 thou/cu mm with the lowest being 377 thou/cu mm. Her platelet count remained at goal between 300 and 350 thou/cu mm after four months of hydroxyurea.

نتیجه گیری

Conclusion


(i) Physicians are faced with several therapeutic challenges when ET coexists with solid tumours.


(ii) )ese should be managed on an individual basis.


(iii) One should take into consideration the risk of thrombosis and the therapeutic approach for solid tumours in the management of these patients.


(iv) Extended VTE prophylaxis during chemotherapy may be needed in select cases.


(v) ET and breast cancer both have favourable outcomes, and therefore, treatment for one should not preclude treatment for the other.


بدون دیدگاه