دانلود رایگان مقاله انگلیسی چگونگی تنظیم نانوذرات و تاثیر آن در بهبود رسانش دارو - 2017 Future Science

“Multiple attempts have been taken to finetune nanoparticles to improve its therapeutic efficiency of drug deliveries, including utilizing conjugated targeting ligands, rational design of reliable linkers between drug and carriers, and integration of the nanoparticle and drugs into different stimulus–response systems.” Drug-delivery systems aim to administer pharmaceutical compounds at a set rate for a preordained length of time and to achieve a therapeutic effect in a continued manner. Major advances have been made in the area of drug delivery systems since the early 1960s, and they have advanced from macroscopic controlled drug delivery devices and implants, to the current era of nanotechnology we are experiencing today [1]. Nanotherapeutic delivery systems present themselves as one of the most promising of their kind. As a drug delivery concept in nanotechnology, it strives to develop nanoscale materials for selective infusion of therapeutic drugs or pharmaceutical compounds to specific cells. It consists of submicron-sized colloidal particles such as nanoparticles, micelles, liposomes and vesicles [2]. These sophisticated materials have shown compelling results in their ability to transport a diverse range of pharmaceutical compounds to various parts of the human system including cells, tissues and organs for sustained periods of time [3–5]. Many biological processes in our bodies rely heavily on subcellular units that exist in the nanoscale (i.e., virus, ribosomes and molecular motors).

Conclusion

Nanotherapeutic delivery strategies have great potential to overcome problems associated with normal drug delivery methods attributed to their improved pharmacokinetics and pharmacodynamics [19]. This is especially so in the area of anticancer therapeutics, where almost all chemotherapeutic agents suffer from one or more of such issues [20]. In general, nanoparticles have tunable surface chemistry and it is this quality that allows for intriguing opportunities to overcome issues of drug resistance in target cells and facilitate movement of drugs across barriers for a better therapeutic efficacy.