Postmenopausal osteoporosis (PMOP) is a systemic chronic bone metabolic disease caused by the imbalance between bone formation and bone resorption mediated by estrogen deficiency. Both exercise and natural extracts are safe and effective means to prevent and control PMOP. +e additive effect of exercise synergy extract against PMOP may be no less than that of traditional medicine. However, the mechanism of action of this method has not been clarified in detail. A large number of studies have shown that the pathogenesis of PMOP mainly involves the OPG-RANKL-RANK system, inflammation, and oxidative stress. Based on the abovementioned approaches, the present study reviews the anti-PMOP effects and mechanisms of exercise and natural extracts. Finally, it aims to explore the possibility of the target of the two combined anti-PMOP through this approach, thereby providing a new perspective for joint intervention research and providing a new direction for the treatment strategy of PMOP.
1. Introduction
Postmenopausal osteoporosis (PMOP) refers to women after menopause due to ovarian atrophy, functional degeneration, and estrogen secretion lack, which then induces a reduction in bone mass, bone trabecular structure changes, bone fragility, and easy fracture systemic bone metabolic disease. +e traditional prevention method for PMOP mainly uses estradiol and bisphosphonates, but long-term use of such drugs may improve the incidence of cancer and osteonecrosis risk [1]. At present, 200 million women worldwide suffer from osteoporosis. It is expected that by 2050, the number of patients with osteoporotic fractures will double compared with now, which represents a huge medical care and economic burden [2]. Based on this, a proposed study explores the effect of exercise combined with natural extracts on postmenopausal osteoporosis.
3. Conclusions
In a summary, it is possible that motor binding to natural extracts may involve multiple pathways including mechanical signaling, estrogen deficiency-mediated OPG/ RANKL alterations, and anti-inflammatory and antioxidant control of PMOP. Most of the existing studies have shown the additive effect of combination interventions, but several data show no additional efficacy, which may be affected by the choice of exercise regimen and extract dosage. +erefore, the effect and mechanism of combination treatment still need to be further explored by extensive experimental data. Exercise and natural ingredients have great potential and advantages with their low cost, nontoxic, and other advantages, which have been widely valued by the medical community. We are eager to select the best treatment scheme based on various therapies in the future to greatly reduce the pain of patients with osteoporosis and help potential patients stay away from the threat of osteoporosis.
