دانلود رایگان مقاله درمان حساسیت شدید عاج دندان با استرانسیم، شبکه های مبتنی بر پلیمر کربوهیدرات

ABSTRACT

This study describes the design/physicochemical properties of strontium-containing, mucoadhesive carbohydrate polymeric platforms, designed as treatments for dentine hypersensitivity. Interactive networks were composed of strontium chloride (10% w/w), one of two base polymers (sodium carboxymethylcellulose, NaCMC or hydroxyethylcellulose, HEC), polycarbophil (PC) and, when required, polyvinylpyrrolidone (PVP). The physicochemical properties were characterised using oscillatory and flow rheometry, texture profile analysis, mucoadhesion analysis and, additionally, the strontium release properties were examined. All platforms exhibited pseudoplastic flow. Increasing polymer concentrations increased network viscoelasticity, consistency, hardness, compressibility, gel strength, adhesiveness, mucoadhesion and, retarded strontium release. Principally zero-order strontium release was observed from all platforms. Incorporation of strontium reduced the network elasticity, consistency, hardness, compressibility, gel strength and mucoadhesion; HEC-based platforms being affected to a greater extent than NaCMC platforms. NaCMC-based platforms containing 10% strontium chloride, PVP (3% w/w) and PC (3% w/w) potentially displayed the correct balance of physicochemical properties for the treatment of dentine sensitivity.

4. Conclusions

This study describes the design and physicochemical properties of strontium-containing, mucoadhesive polymeric platforms designed for the enhanced treatment of dentine hypersensitivity. Polymeric networks were designed composed of NaCMC or HEC, PC and, optionally PVP and 10% w/w strontium chloride. Increasing polymer concentration significantly increased elasticity, dynamic viscosity, gel strength, hardness, compressibility, adhesiveness and mucoadhesion. All platforms exhibited pseudoplastic flow. Incorporation of strontium chloride decreased the magnitude of the aforementioned parameters, due to the interaction of strontium ions with the anionic polymeric component(s). The release of strontium from the NaCMC-based and HEC-based platforms was essentially zero-order, the release from Na-CMC platforms being slower than from their HEC-based counterparts. The relevance of the methods used to characterise the polymeric platforms to clinical performance allows the preferable candidates for potential clinical evaluation to be identified. The preferred packaging for these platforms is the standard ointment tube, thus allowing platforms with a wide range of hardness and compressibility to be administered. Without an obvious restriction on the flow properties ofthe platforms from the packaging, platforms may be selected that offer high elasticity, adhesiveness and mucoadhesion. Furthermore,the choice of NaCMC as the base-polymer ismore appropriate given the greater resistance to strontium-associated reductions in the rheological properties and is more clinically appropriate given the combination of enhanced mucoadhesive and strontiumcontrolled release properties. In this respect, it is suggested that NaCMC-based platforms containing 10% strontium chloride, PVP (3% w/w) and PC (3% w/w) will offer particular promise in this regard and serve as a novel strategy for the treatment of dentine hypersensitivity by means ofthe simultaneous prolonged retention at the tooth surface and hence blockage of fluid flow and strontium delivery to the dentinal tubules.