دانلود رایگان مقاله انگلیسی کیتوزان مبتنی بر داربست و کاربردش در بهبود زخم - نشریه الزویر

Abstract

Over the last decade, much interest has been developed in biopolymer based materials due to their biocompatible, biodegradable, non-toxic and non-allergenic nature. Chitosan is a unique biopolymer that exhibits outstanding properties, besides biocompatibility and biodegradability. Most of these peculiar properties arise from the presence of primary amines along the chitosan backbone. Many works have been done to obtain chitosan based scaffolds, including surface modifications, the fabrication of chitosan based blends, chitosan based composite scaffolds, and drug-loaded scaffolds. This study provides an overview of the key features of inherent properties of chitosan, their modification, and its use in biomedical engineering particularly toward anti-inflammatory and wound healing.

Conclusions and Future Prospective

In this review, the various properties such as antimicrobial, anti-inflammatory and biomedical applications of chitosan based materials especially wound dressings have been covered. Chitosan has been shown to be a potential biomaterial to be used in wound healing due to its antimicrobial and anti-inflammatory nature. Effective dressings should have characteristics optimized for particular type of wound at a reasonable low cost and with minimum inconvenience to patients. Many results have been reported, but complete and standard characterization of these materials is needed. Therefore, there is need to manipulate the physical properties of identified systems to achieve such objectives. Although a lot of literature is available on chitosan and modified chitosan (blends/composites/derivatives) for wound healing, there are many challenges which need to be explored in process of wound healing. We expect that this article will provide insights on the use of these important chitosan based materials for researchers working in the field of biomedical and pharmaceutical sciences