دانلود رایگان مقاله فعالیت ضد میکروبی عصاره گونه های تریکودرما

abstract

Mangrove environment holds a rich source for discovery of novel microbiota with potential applications in pharmaceutical science. Marine derived fungi are known to produce secondary metabolites with excellent biomedical applications when compared with that of terrestrial origin. The marine fungi produce bioactive compounds that could be used as a promising source to cure the human and fish diseases. Bearing this in mind, the rhizosphere fungi were isolated and tested for their antimicrobial properties. The potent fungal strain was chosen and subjected for mass scale cultivation followed by the extraction of secondary metabolites with ethyl acetate. The crude extract was examined for anti microbial and antioxidant properties. The results clearly states that the Trichoderma isolated from mangrove sediment are capable of suppressing the growth of human pathogens rather than fish pathogens and also hold significant antioxidant properties.

4. Conclusion

Totally, 13 strains were isolated from the rhizosphere of R. annamalayana in Pichavaram mangrove forest. The crude extract of the potent fungi was characterized by FTIR analysis and subjected for antimicrobial and antioxidant properties. It is evident from the present study that the marine environment harbors a potential source of bioactive metabolites. The crude ethyl acetate extracts of marine derived Trichoderma sp., exhibited a promising anti microbial activity against both the human and fish pathogens in a dose dependent manner. Comparing to both, the crude extract showed potential activities against human pathogens rather than fish pathogens. Owing to its increased free radical scavenging activity, further investigation on the purification of this metabolite will provide novel and efficient secondary metabolites towards developing potent antimicrobials.