دانلود رایگان مقاله انگلیسی داروهای ضد افسردگی در صرع - الزویر 2018

عنوان فارسی
داروهای ضد افسردگی در صرع
عنوان انگلیسی
Antidepressants in epilepsy
صفحات مقاله فارسی
0
صفحات مقاله انگلیسی
5
سال انتشار
2018
نشریه
الزویر - Elsevier
فرمت مقاله انگلیسی
PDF
نوع مقاله
ISI
نوع نگارش
مقالات مروری
رفرنس
دارد
پایگاه
اسکوپوس
کد محصول
E9500
رشته های مرتبط با این مقاله
پزشکی
گرایش های مرتبط با این مقاله
مغز و اعصاب
مجله
مجله مغز و اعصاب و جراحی مغز و اعصاب لهستان - Neurologia i Neurochirurgia Polska
دانشگاه
Department of Psychiatry - Faculty of Medicine - Medical University of Gdańsk - Gdańsk - Poland
کلمات کلیدی
داروهای ضد افسردگی، صرع، خطر تشنج، دارو درمانی
doi یا شناسه دیجیتال
https://doi.org/10.1016/j.pjnns.2018.07.005
چکیده

abstract


People with epilepsy (PWE) frequently suffer from comorbid mood and anxiety disorders. Depression is one of the major psychiatric comorbidities having a negative impact on the quality of life in people with epilepsy. A review of the literature indicates that the majority of antidepressant-related seizures have been associated with either ultra-high doses or overdosing and, generally, the risk of antidepressant-associated seizures is low. Correspondingly, there is some evidence indicating that antidepressants of most widely used groups may additionally lower the risk of triggering seizures. Four antidepressants are not recommended for patients with epilepsy, i.e.: amoxapine, bupropion, clomipramine and maprotiline. Clinicians applying first line of depression treatment in patients with epilepsy should consider use of SSRIs or SNRIs, particularly sertraline, citalopram, mirtazapine, reboxetine, paroxetine, fluoxetine, escitalopram, fluvoxamine, venlafaxine, duloxetine. Implementation of anticonvulsive drugs in depressed patients should include valproate, carbamazepine, lamotrigine, gabapentin, pregabalin. The paper reviews the evidence for the clinical use of antidepressants in PWE.

نتیجه گیری

6. Conclusion


In summary, indication for best practice for ADT in PWE is: SSRIs or SNRIs including citalopram, escitalopram, sertraline, fluoxetine, mirtazapine, reboxetine, paroxetine, fluvoxamine, venlafaxine and duloxetine. With the exception of four drugs (amoxapine, bupropion, clomipramine and maprotiline) antidepressant drugs are generally safe for PWE when used at therapeutic doses. The discerning insight into this issue may lead to a supposition, that antidepressant drug-induced convulsions are rather a result of an overdose or slow metabolism which results in high plasma concentrations of antidepressants [51]. Data appear to reaffirm previous observations derived from open trials that SSRIs and SNRIs do not aggravate seizure frequency and therefore should be used for the treatment of comorbid mood disorders in PWE [6,19–21].


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