
ترجمه مقاله نقش ضروری ارتباطات 6G با چشم انداز صنعت 4.0
- مبلغ: ۸۶,۰۰۰ تومان

ترجمه مقاله پایداری توسعه شهری، تعدیل ساختار صنعتی و کارایی کاربری زمین
- مبلغ: ۹۱,۰۰۰ تومان
abstract
People with epilepsy (PWE) frequently suffer from comorbid mood and anxiety disorders. Depression is one of the major psychiatric comorbidities having a negative impact on the quality of life in people with epilepsy. A review of the literature indicates that the majority of antidepressant-related seizures have been associated with either ultra-high doses or overdosing and, generally, the risk of antidepressant-associated seizures is low. Correspondingly, there is some evidence indicating that antidepressants of most widely used groups may additionally lower the risk of triggering seizures. Four antidepressants are not recommended for patients with epilepsy, i.e.: amoxapine, bupropion, clomipramine and maprotiline. Clinicians applying first line of depression treatment in patients with epilepsy should consider use of SSRIs or SNRIs, particularly sertraline, citalopram, mirtazapine, reboxetine, paroxetine, fluoxetine, escitalopram, fluvoxamine, venlafaxine, duloxetine. Implementation of anticonvulsive drugs in depressed patients should include valproate, carbamazepine, lamotrigine, gabapentin, pregabalin. The paper reviews the evidence for the clinical use of antidepressants in PWE.
6. Conclusion
In summary, indication for best practice for ADT in PWE is: SSRIs or SNRIs including citalopram, escitalopram, sertraline, fluoxetine, mirtazapine, reboxetine, paroxetine, fluvoxamine, venlafaxine and duloxetine. With the exception of four drugs (amoxapine, bupropion, clomipramine and maprotiline) antidepressant drugs are generally safe for PWE when used at therapeutic doses. The discerning insight into this issue may lead to a supposition, that antidepressant drug-induced convulsions are rather a result of an overdose or slow metabolism which results in high plasma concentrations of antidepressants [51]. Data appear to reaffirm previous observations derived from open trials that SSRIs and SNRIs do not aggravate seizure frequency and therefore should be used for the treatment of comorbid mood disorders in PWE [6,19–21].