دانلود رایگان مقاله آیا شاخص توده بدنی زنان نابارور بر روش و نتیجه IVF تاثیرگذار است؟

INTRODUCTION

Higher risks of infertility have been found in both overweight and underweight women (1–3). To appreciate female anthropometry the estimation of Quetelet’s body mass index (BMI) defined as weight/height2 (kg/m2 ) is frequently performed. According to this parameter, a BMI range from 20 to 25 kg/m2 corresponds to normal weight women, whereas a BMI between 25 and 28 kg/m2 defines overweight women and BMI equal to or greater than 28 kg/m2 defines obese women. The prevalence of overweight varies worldwide but is estimated to range from 5% (4) to more than 30% (5) in developed countries. Overweight repercussions on fertility are well known. In natural cycles, the fertility of obese women is lower compared to normally weighted women (2) and ovulation disorders are more frequent (5). In case of pregnancy, the miscarriage rate increases (5) with maternal obesity and also is a factor associated with an increased risk of cesarean delivery (6). Concerning infertility treatments, it has been demonstrated that response to gonadotropins for follicular growth is inversely related to body mass (7). In addition the length of the stimulation protocol (8) the number of retrieved oocytes (9) also seem to be disturbed by an increased BMI.

CONCLUSIONS

The effects of extremes of patients’ body mass on the IVF procedure and outcome still remain a controversial subject (12). In the described study, different parameters are impaired in overweight as well as in underweight patients, leading to decreased chances of normal pregnancy.