دانلود رایگان مقاله تغییر عملکرد آنورکتال با اختلال در خواب و اختلال اتونوم

Summary

Background: We aimed to investigate whether disruption of the circadian rhythm in rotating shift work (RSW) workers would change anorectal motility and cardiac autonomic function. We also determined whether sleep and psychological status (e.g., anxiety and depression) would affect anorectal motility in RSW workers. Methods: Sixteen RSW workers and 11 control individuals were involved in the study. All study participants underwent anorectal manometry and spectral analysis of heart rate variability. All participants completed three questionnaires: the Pittsburgh Sleep Quality Index (PSQI), the State-Trait Anxiety Inventory (STAI) questionnaire, and the Taiwanese Depression Questionnaire (TDQ). Results: The RSW workers had a lower threshold volume for maximal urge (p Z 0.006) and greater rectal compliance (p Z 0.02), compared to the controls. The RSW workers had a greater PSQI score (p Z 0.002) and TDQ score (p Z 0.003), compared to the controls. The RSW workers had a significantly increased low-frequency power percentage (LF%), compared to the controls (p Z 0.03). The RSW workers had a significant correlation between the resting anal sphincter pressure and high-frequency power percentage (HF%; r Z e0.62, p Z 0.01), and between the R-R interval and the threshold for maximal urge (r Z 0.51, p Z 0.04). The PSQI score was significantly correlated with the threshold volume for urge (r Z 0.55, p Z 0.03) and for compliance (r Z 0.51, p Z 0.04) in the RSW workers.

Discussion

Autonomic nervous system regulation of the heart rate, as evidenced by noninvasive measurements of HRV, was applied in this study to detect changes in the ANS functions in RSW workers. In this study, we determined various parameters of HRV in a cohort of RSW workers and healthy controls in whom the differences in autonomic regulation were further investigated. In agreement with other studies [15,28], we observed a predominant shift in cardiac autonomic regulation toward sympathetic balance, as indicated by a significantly increase in LF%, compared to the healthy controls. Our investigation using a noninvasive method of HRV analysis is able to characterize the changes in the ANS functions in RSW workers, which suggests that such individuals may have a risk for long-term sympathetic hyperactivity.