دانلود رایگان مقاله پودر چاپ 3D برای مهندسی بافت استخوان

Abstract

Bone tissue engineered 3-D constructs customized to patient-specific needs are emerging as attractive biomimetic scaffolds to enhance bone cell and tissue growth and differentiation. The article outlines the features of the most common additive manufacturing technologies (3D printing, stereolithography, fused deposition modeling, and selective laser sintering) used to fabricate bone tissue engineering scaffolds. It concentrates, in particular, on the current state of knowledge concerning powder-based 3D printing, including a description of the properties of powders and binder solutions, the critical phases of scaffold manufacturing, and its applications in bone tissue engineering. Clinical aspects and future applications are also discussed.

4. Conclusions

The current state of art concerning powder-based 3DP for bone tissue engineering has been reviewed and discussed here. In vitro and in vivo investigations examining 3D printed scaffolds have uncovered promising results confirming their utility for bone regeneration. CaP ceramics appear to be particularly attractive materials for tissue engineering. There are still, however, many unanswered questions concerning critical aspects linked to depowdering and the cytocompatibility and osteoconductive properties of bone substitutes produced using 3D printing technology. Further studies focusing on critical-sized bone defects are warranted to gain more detailed knowledge about potential clinical applications. This approach, in fact, has opened the way to fabricating customized bone scaffolds with complex internal and external structures that exactly mirror the dimensions of bone defects.