دانلود رایگان مقاله انگلیسی خدمات ارائه گواهی رسمی مبتنی بر بلاک چین برای بازیابی دانش زیست پزشکی - الزویر 2018

abstract

Biomedical research and clinical decision depend increasingly on scientific evidence realized by a number of authoritative databases, mostly public and continually enriched via peer scientific contributions. Given the dynamic nature of biomedical evidence data and their usage in the sensitive domain of biomedical science, it is important to ensure retrieved data integrity and non-repudiation. In this work, we present a blockchain-based notarization service that uses smart digital contracts to seal a biomedical database query and the respective results. The goal is to ensure that retrieved data cannot be modified after retrieval and that the database cannot validly deny that the particular data has been provided as a result of a specific query. Biomedical evidence data versioning is also supported. The feasibility of the proposed notarization approach is demonstrated using a real blockchain infrastructure and is tested on two different biomedical evidence databases: a publicly available medical risk factor reference repository and on the PubMed database of biomedical literature references and abstracts.

Discussion

This paper proposes a query notary for biomedical data consumers (humans or programs alike) who need to retrieve accurate and certified data from reference biomedical databases. The proposed approach utilizes blockchain technology and is implemented using a real blockchain infrastructure for two different publicly available medical reference repositories. The goal of this work is to provide a state of the art solution for ensuring integrity and non-repudiation of information retrieval operations when life-critical biomedical and clinical evidence is involved. The proposed biomedical database query notary service exhibits two different schemes to cover the different scenaria of use. The first scheme (basic) implements a query-response ledger by which the user attains a sealed proof that at a specific time a specific query has been placed in a biomedical database which returned specific results. This scheme can be used to seal the integrity and non-repudiation of a query and the retrieved results when a critical biomedical task depends on the specific query. An example could include the case where a biomedical literature database is queried to acquire state of the art medical evidence to carry out a systematic review or even to construct clinical guidelines. The second scheme (versioning) allows for non-reputable versioning of information retrieved from a dynamically evolving biomedical database at a number of occasions in time, always via the same query. This versioning scheme could be used to seal different versions of evolving medical evidence as retrieved from a biomedical database with content that is continually updated. An example could involve a health application which uses medical evidence as provided by a dynamic biomedical database for decision support in healthcare; using the versioning scheme the health application can ensure the integrity and non-repudiation of its knowledge base at any given point in time.