دانلود رایگان مقاله حفاظت کبد پلی ساکارید میسلیوم روی آنزیمی استخراج شده توسط قارچ پلوروتوس ارینگی

abstract

The purpose of this work was designed to investigate the hepatoprotective and antioxidant effects of enzymatic-extractable mycelia zinc polysaccharides (En-MZPS) from Pleurotus eryngii var. tuoliensis on the hyperlipidemic mice induced by high-fat-high-cholesterol emulsion (HFHCM). The results showed that the supplementation of En-MZPS had potential anti-hyperlipidemia effects on reducing hepatic lipid levels by monitoring the serum enzyme activities (ALP, ALT and AST) and serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), enhancing the antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), and decreasing the lipid peroxidation (MDA and LPO). Furthermore, the in vitro scavenging results indicated that the inhibition effects of En-MZPS on hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals reached 59.98 ± 6.29% and 37.01 ± 2.15%, respectively. These conclusions demonstrated that the En-MZPS might be suitable for functional foods and natural drugs in preventing the HFHCM-induced hyperlipidemia and non-alcoholic fatty liver.

5. Conclusions

In the present work, a novel enzymatic-extractable zinc polysaccharide (En-MZPS) with major component of glucose was isolated from the mycelia of P. eryngii var.tuoliensis. The results showed that En-MZPS exhibited impressive prevention effects on the HFHCEinduced hyperlipidemia in mice paralleled with simvastatin as a prophylactic agent, suggesting that En-MZPS from P. eryngii var. tuoliensis had a potential in the prevention and treatment with hyperlipidemic and liver damage induced by HFHCE.