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دانلود رایگان مقاله انگلیسی سنتز هیدروکسی آپاتیت آلاییده مونوفازیک و ارزیابی فعالیت آنتی باکتریال – الزویر ۲۰۱۸

عنوان فارسی: سنتز هیدروکسی آپاتیت آلاییده مونوفازیک و ارزیابی فعالیت آنتی باکتریال
عنوان انگلیسی: Synthesis of monophasic Ag doped hydroxyapatite and evaluation of antibacterial activity
تعداد صفحات مقاله انگلیسی : 6 تعداد صفحات ترجمه فارسی : ترجمه نشده
سال انتشار : 2018 نشریه : الزویر - Elsevier
فرمت مقاله انگلیسی : PDF نوع مقاله : ISI
نوع نگارش : مقالات پژوهشی (تحقیقاتی) پایگاه : اسکوپوس
کد محصول : E9531 رفرنس : دارد
محتوای فایل : PDF حجم فایل : mb 1
رشته های مرتبط با این مقاله: شیمی
گرایش های مرتبط با این مقاله: شیمی معدنی
مجله: علوم مواد و مهندسی - Materials Science & Engineering C
دانشگاه: Physics Department - Lahore College for Women University - Lahore - Pakistan
کلمات کلیدی: مواد بیولوژیکی، هیدروکسی آپاتیت، نقره، فعالیت ضد باکتری
doi یا شناسه دیجیتال: https://doi.org/10.1016/j.msec.2018.04.076
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چکیده

ABSTRACT

The present study aims to synthesized biomaterial that has antibacterial properties. Currently the surgical implants associated infections are a major cause of implant failure. Synthesis of silver doped hydroxyapatite as an antibacterial agent has potential importance to overcome post-surgical infections in a variety of clinical applications. Five silver doped hydroxyapatite Ca10−xAgx(PO4)6(OH)2 (x = 0, 0.1, 0.3, 0.5, 0.7 M) samples were synthesized by precipitation method and sintered at 900 °C to obtain well crystallized structure. No minor phase developed with silver addition, hexagonal hydroxyapatite (JCPDS# 09-432) was the single phase identified in all silver doped hydroxyapatite samples. The lattice parameter a and c changed with increase in silver concentration. The results of in vitro bioactivity revealed the bone bonding ability of silver doped hydroxyapatite samples. The antibacterial test showed that silver doped hydroxyapatite was sensitive to Staphylococcus aureus bacteria. Addition of silver significantly (P < 0.005) increased the antibacterial activity.

نتیجه گیری

4. Conclusion

Monophasic silver doped hydroxyapatite was successfully synthesized by precipitation method and it was confirmed by XRD, FTIR and Raman spectroscopy. The analysis showed that a single phase of hexagonal hydroxyapatite was identified in all silver doped hydroxyapatite specimens with no minor phase, which indicates that Ag+ was well substituted in lattice without disturbing the crystal structure. It was observed that 7% (0.7 M) of Ag+ substituting in the Ca+2 site and sintering at 900 °C are the optimum limit to obtain monophasic hydroxyapatite crystalline structure. In vitro bioactivity test in SBF confirmed the bone-bonding ability of silver doped hydroxyapatite. The antibacterial assays showed that all silver doped hydroxyapatite samples had the bacteria inhibition ability and antibacterial activity increases significantly with increase in concentration of Ag+. The undoped sample had limited antibacterial activity against Staphylococcus aureus while addition of Ag+ enhanced antibacterial activity. From the present study it can be suggested that silver doped hydroxyapatite possessing antibacterial activity is a potentially good biomaterial for bone tissue engineering that can limit the risk of post-surgical infections caused by bacteria colonization.