ترجمه مقاله آماده سازی نانو کپسول های سولفات آهنی لیپوزومی با متد تبخیر مرحله معکوس

Iron is a vital metal for doing body ess ential activities. But reacting this metal with other nutrients or medicines can prevent iron effective absorption in body. One of the best ways for increased iron absorption is the encapsulation. This method minimizes iron interactions and maximizes its absorption. In the research for this objective achievement, Liposome used as nanoparticles cover, due to two-layer phospholipid structure and its similarity with cell membrane, low natural toxicity, biocompatibility and biodegradability; and Polyethylene glycol 2000(PEG2000) due to increasing nanocapsules structure stability. Also Ferrous sulfate selected as nanoparticles core, due to increase in amount of absorption than other ferrous components and effective solubility in the water and the digestive system. Then nanocapsules were prepared by reverse-phase evaporation method and were separated by Refrigerated Centrifuge(30 min, 4˚C, 14000 rpm) and were finally dried with Lyophilized-Edwards high vacuum devices(-20˚C). Physical structure stability, diameter and morphology of nanocapsules were respectively examined by zeta-sizer and Scanning Electron Microscope(SEM). Results showed, all synthetic nanocapsules had the spherical form, diameter about 300 nm and high stability to produce dietary supplementary tablet. In addition, amount of Encapsulation Efficiency (EE) and loading were respectively obtained 75.55% and 7.98%. As a result nanocapsules core will have the most physical stability and structure durability to release medicine in special part of the body. Also, this synthetic product will probably resolve apparent and organoleptic problems which are originated iron in most of the industries especially food and medicinal industries.