دانلود رایگان مقاله انگلیسی مکانیسم کنترل تشنج ابسنس با محرک مغزی عمیق اعمال شده در هسته زیر تالاموسی - اشپرینگر 2017

Abstract

Based on a classical model of the basal ganglia thalamocortical network, in this paper, we employed a type of the deep brain stimulus voltage on the subthalamic nucleus to study the control mechanism of absence epilepsy seizures. We found that the seizure can be well controlled by turning the period and the duration of current stimulation into suitable ranges. It is the very interesting bidirectional periodic adjustment phenomenon. These parameters are easily regulated in clinical practice, therefore, the results obtained in this paper may further help us to understand the treatment mechanism of the epilepsy seizure.

Conclusion

Epilepsy is a kind of chronic disease, it will last for years, even decades, and has serious negative impact on patient’s physical, mental, marital and social economy, etc. Therefore, we should pay enough attention to the treatment of patients with epilepsy. Control is the most important strategy in the treatment of epilepsy. In this paper, based on a theoretical model, we changed the period and duration of stimulation current to study the control mechanisms of absence seizures. We can see from the numerical simulation results that seizures can be controlled effectively by turning the period and duration of current stimulation into suitable ranges. It is a very interesting bidirectional periodic adjustment phenomenon. However, the control effect is not obvious by changing the magnitude of the current. Of course, this program is also little used in clinical medicine and experimental research at present. The target choosed is the STN, which is also the most commonly used deep brain stimulation target area in clinical medicine. The current parameters P and D studied in this paper may be easily regulated by the high tech clinical experiment technology, therefore, we hope that the obtained results can provide a valuable theoretical reference for clinical and experimental research in future.