Abstract
Diabetes mellitus is a worldwide health problem affecting 1–2% of the population of world with noticeable morbidity and mortality. Vascular events such as hypertension, nephropathy, neuropathy and retinopathy are happened in diabetic patients. Decline in tissue blood circulation may causes hypoxia and finally may leads to slow wound healing and amputation. PVA/Chitosan Nano fiber wound dressings have high moisture vapor transmission rate and good antimicrobial activity1 PCNWD substrate does not have any recognized cytotoxicity effects and has excellent odor absorbing capability. In the present study, Streptozotocin (STZ) is used to induce diabetes in rats, Skin ulcers are produced experimentally in the experimentally induced diabetic and non-diabetic rats. Then PCNWD used as wound dressing for 2 weeks period to evaluate its macroscopic and microscopic effects on wound healing in comparison with untreated diabetic and non-diabetic rats experimental ulcers. The findings of current study indicate significant acceleration in diabetes wound healing on the rats treated by PVA/Chitosan Nano fiber.
1. Background
There were 131 million diabetic people in 2000, worldwide, and it is estimated to be increased to 366 million people by 2030 [1]. Diabetes mellitus is characterized by a dysfunction in glucose metabolism associated with consequently considerable negative effects on lipid and protein metabolisms. Diabetes should be controlled, otherwise, diabetic patients may face complications in both short-term and long-term periods [2]. In general, diabetes ketoacidosis and hyperosmolar hyperglycaemic nonketotic coma (HONK) are considered as acute complications of diabetes [3,4]. Chronic complications of diabetes can be categorized into three general groups: nerve damage (neuropathy), macrovascular disease (disease of the large blood vessels), damage to small blood vessels such as capillaries (microvascular diseases) [5].
4. Discussion
In the present study, streptozotocin was used to induce experimental diabetes in the rats. Streptozotocin can prevent DNA synthesis in the mammals and bacterial cells. In the bacterial cells, it can lead to a special reaction with cytosine groups, resulting in degeneration and destruction of DNA. Mammalian cell death is owing to its biochemical mechanism. Streptozotocin can prevent cellular reproduction with the less doses needed for inhibiting the substrate connection to the DNA or inhibiting several enzymes involved in DNA synthesis [12].
