دانلود رایگان مقاله موردی برای گیاه ساخته شده ایمونوتراپوتیک دامپزشکی

Abstract

The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval.

7. Conclusions

Issues surrounding the presence of adventitious agents, especially prions, in mammalian cell production systems have been a concern with regulators and the public. The use of plants for the production of veterinary vaccine components for oral or parenteral delivery would circumvent these issues and can offer advantages in terms of safety, cost, and facilitated regulatory approval. While no plant-made veterinary vaccines or antibodies appear in the pipeline of regulators in Canada or the USA, research is actively pursued by several academic and government laboratories that may pave the way for new products in the near future. Strategies to improve yield and purification from plants have achieved significant progress; while advantages for oral delivery, a route that is the practical choice for convenience of animal mass immunization, include protection in the gastro-intestinal tract and the potential for incorporation into highly immunogenic, self-assembling VLPs. These advantages make plants an attractive platform for the production of cost-effective immunotherapeutics, which can contribute to lowering reliance on antibiotics in agriculture.