The Spread of Oncology-Related Diseases Depending on Environmental Stress
The second half of the 20th century was characterised by rapid growth of malignant tumours in worldwide population. This is associated with a qualitative change in the environment (Remennik and Starinskiy, 2000; Trapeznikov and Axel, 2000; Zaridze, 2000; Howe, 2006; Kiku et al., 2012). Among the risk factors of malignancy development are adverse lifestyle factors (45.00%), environment pollution (19.00%), and genetic risk (26.00%) (IARC Monographs on the Evaluation of Cancirogenic Risk to Humans, 2002; Chissov et al., 2007). According to several authors, greater than 80–90% of malignant tumours result from external factors (Smulevich, 2003; Roe, 2004). The uneven spread of cancer diseases in different regions and the change in incidence of migration conclusively establish the link between cancer and ecological features of human existence (Stern, 2003; Russo and Franceschi, 2006; Schraub, 2009). Onco-epidemiological studies identified the role of environmental factors on tumorigenesis. According to the WHO Committee on cancer prevention, up to 90.00% of tumours are associated with environmental factors, and the remaining 10% are caused by viral, genetic and other endogenous factors (Higginson, 2005). The results of onco-epidemiology studies indicate that the carcinogenic environmental factors and lifestyle cause 90–95% of malignant tumours (Zaridze, 2000; Longnecker, 2005; Kelsey and Bernstein, 2006)