دانلود رایگان مقاله انگلیسی وضعیت ویتامین D و عوامل خطر مرتبط با آن در میان بزرگسالان - هینداوی 2018

Background

Vitamin D has been shown to exert its actions on the musculoskeletal, gastrointestinal, prostate, renal, endocrine, immune, and cardiovascular systems. Current reported data of hypovitaminosis D reveals a global pandemic, with an estimated one billion people worldwide presenting with hypovitaminosis D. Objective. *is study aimed at investigating the vitamin D status and its associated risk factors in Cameroonians from the South West Region. Method. *e study was a community- and hospitalbased prospective longitudinal study. It was carried out during the dry and rainy seasons between the months of July and December 2015 in the South West Region of Cameroon involving 372 participants aged 35 years and above. After obtaining informed consent, a structured questionnaire was used to capture demographic data and risk factors of vitamin D deficiency. Blood samples were collected from the volunteer participants in the peak months of the rainy season and dry season, and the serum used to analyse for vitamin D by ELISA and calcium by spectrophotometry. 25(OH)D levels ≥75 nmol/L (≥30 ng/mL) were considered sufficient while levels <75 nmol/L were considered as hypovitaminosis D (insufficiency/deficiency). Results. Hypovitaminosis D (deficiency/insufficiency) was prevalent in 25.8% (96) of the study population, with only 3.2% (12) deficiency and 22.6% (84) insufficiency. *ere was a significant inverse relationship (r � −0.119, p � 0.02) between age and 25(OH)D levels; however, this relationship was not significant when controlled for gender, number of hours spent outdoors, and percentage of body covered. Gender, ethnic origin, percentage of body covered, time spent outdoors, and season did not influence serum vitamin D levels. Conclusion. Results of this study suggest that the prevalence of hypovitaminosis D is relatively low in this study population and only age is a risk factor of vitamin D deficiency.

Discussion

The overall prevalence of vitamin D levels below 75 nmol/L (hypovitaminosis D) in this study was 25.8% and only 3.2% presented with overt deficiency (<50 nmol/L; <20 ng/mL). *is finding is similar to results previously obtained among elderly people in some villages in Kumba health district in 2002 where 24% of the study participants presented with hypovitaminosis D [15]. Results similar to our finding were reported in a study in Malaysia involving Chinese and Malaysian men aged 20 and above with hypovitaminosis D of 23.2% [5]. *e similarity with our study could be as a result that they included a wider range of age groups as this study, and also our dressing style is similar to the Chinese. Also a study of traditionally living populations in East Africa with expected maximum sun exposure due to extensive outdoor activities with light dressing revealed no vitamin D deficiency and only 13.3% vitamin D insufficiency [20], confirming that lifestyle greatly influences vitamin D status.