دانلود رایگان مقاله انگلیسی طیف سنجی جرم و پروتئومیک در هماتولوژی - الزویر 2018

عنوان فارسی
طیف سنجی جرم و پروتئومیک در هماتولوژی
عنوان انگلیسی
Mass spectrometry and proteomics in hematology
صفحات مقاله فارسی
0
صفحات مقاله انگلیسی
25
سال انتشار
2018
نشریه
الزویر - Elsevier
فرمت مقاله انگلیسی
PDF
نوع مقاله
ISI
نوع نگارش
مقالات مروری
رفرنس
دارد
پایگاه
اسکوپوس
کد محصول
E9614
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پزشکی
گرایش های مرتبط با این مقاله
خون شناسی
مجله
سمینارها در هماتولوژی - Seminars in Hematology
دانشگاه
Department of Pathology and Laboratory Medicine - University of Pennsylvania Perelman School of Medicine - PA
کلمات کلیدی
طیف سنجی جرمی، پروتئومیک، هماتولوژی
doi یا شناسه دیجیتال
https://doi.org/10.1053/j.seminhematol.2018.05.009
چکیده

Abstract


Mass spectrometry-based techniques now enable the unbiased identification of proteins in complex mixtures including proteins isolated from cells and tissues. These powerful tools permit near-complete annotation of proteins expressed in cells, tissues or organs. Further, these techniques permit the interrogation of the numerous post translational modifications that govern cell-specific responses to signaling cues and underlie the functional heterogeneity of cellular composition and contribute to biological complexity. Parallel developments in technologies such as mass cytometry and multicolor ion-beam imaging which permit multi-parameter detection of numerous proteins at the single cell and in-situ level respectively are poised to radically impact our understanding of the functional and translational importance of proteins in hematologic conditions. Importantly, the field of proteomics is poised to realize the immensely powerful opportunities in integration with genomic information that is being discovered at an unprecedented pace for many hematologic conditions.

نتیجه گیری

Conclusions


Application of MS-based proteomic analysis has contributed broadly to the understanding of many hematologic disorders. The rapid development of sophisticated instrumentation, bioinformatics tools and improved sample interrogation methods and parallel advances in singlecell genomic analyses will provide exciting new opportunities for the enhanced utilization of MS-based proteomics in the investigation and clinical evaluation of hematologic conditions.


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